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The compound received FDA GRAS status for safety but was never approved as a drug because efficacy was insufficient for pharmaceutical registration
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· Scientific Reports · 2018 6Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunctionBabula JJ, Bui D, Stevenson HL, Watowich SJ, Neelakantan H · Diabetes, Obesity and Metabolism · 2024 7Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscleNeelakantan H, Brightwell CR, Graber TG, Maroto R, Wang HL, McHardy SF, Papaconstantinou J, Fry CS, Watowich SJ · Biochemical Pharmacology · 2019 8Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese miceSampson CM, Dimet AL, Neelakantan H, Ogunseye KO, Stevenson HL, Hommel JD, Watowich SJ · Scientific Reports · 2021 9Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged miceDimet-Wiley AL, Latham CM, Brightwell CR, Neelakantan H, Keeble AR, Thomas NT, Noehren H, Fry CS, Watowich SJ · Scientific Reports · 2024 10Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO miceDimet-Wiley A, Wu Q, Wiley JT, Eswar A, Neelakantan H, Savidge T, Watowich S · Scientific Reports · 2022 11PubChem Compound Summary CID 950107, 5-amino-1-methylquinoliniumNational Center for Biotechnology Information · PubChem · 2026 12PubChem Compound Summary CID 66522933, 5-amino-1-methylquinolin-1-ium iodideNational Center for Biotechnology Information · PubChem · 2026 13Noncoupled Fluorescent Assay for Direct Real-Time Monitoring of Nicotinamide N-Methyltransferase ActivityNeelakantan H, Vance V, Wang HL, McHardy SF, Watowich SJ · Biochemistry · 2017 Disclaimer All articles and product information provided on this website are for informational and educational purposes only
